May
24-25
2017

Prof. Mark Lawler

Chair in Translational Cancer Genomics at Queen's University Belfast

Mark is Chair in Translational Cancer Genomics in the Centre for Cancer Research and Cell Biology and Dean of Education for the Faculty of Medicine, Health and Life Sciences at Queen’s University Belfast (QUB). He has published ~170 papers in high impact international journals and received a number of prestigious national and international awards for his research. He is a member of the Global Alliance for Genomics and Health (GA4GH) Clinical Working Group Executive and co-chairs the GA4GH Cancer Task Team with Prof Charles Sawyers (Memorial Sloan Kettering, New York). GA4GH is an international collaborative initiative dedicated to the sharing and mining of clinical and genomic data. Mark’s leadership in promoting a responsible but effective data sharing culture in cancer research and cancer care for the benefit of patients is evidenced by a number of high quality research papers, 1-3 including a marker paper in Nature Medicine. 2 He presented this data sharing blueprint and how it can contribute to global precision health during the United Nations (UN) General Assembly at the UN Building in New York in late 2016.  Mark is the QUB lead for the MRC-CRUK Funded Stratified Medicine Colorectal Cancer Consortium (S:CORT) which is generating/mining high quality ‘omics data from a cohort of over 2,000 patients enrolled in UK-wide colorectal clinical trials and cohort studies. 4 Mark is also active in citizen driven health, leading S:CORT’s Public and Patient Involvement and Engagement Work Stream. As Vice President of the European Cancer Concord (ECC), an equal partnership between patients and healthcare professionals, he was the architect of the European Cancer Patient’s Bill of Rights,5 which he launched on World Cancer Day 2014 in the European Parliament in Strasbourg. He is also Chair of the Research Working Group of the European Alliance for Personalised Medicine (EAPM) and launched their Research Roadmap for Personalised Medicine and Big Data in Europe in Brussels in September 2014. He was recently appointed to the Board of EAPM and is hosting the EAPM Congress “Personalising Your Health: A Global Imperative!) which will take place in Belfast from 27th – 30th November 2017.

Relevant Recent Major Publications

Lawler M*, Sawyers CL on behalf of the GA4GH Cancer Task Team. Sharing clinical and genomic data in cancer: the need for global solutions. N Engl J Med in revision *Corresponding Author

Siu LL, Lawler M*, Haussler D, et al. Facilitating a culture of responsible and effective sharing of cancer genome data. Nat Med. 2016; 22:464-71. *Joint First Author / Corresponding Author

Lawler M*, Siu LL, Rehm HL, Chanock SJ, Alterovitz G, Burn J, Calvo F, Lacombe D, Teh BT, North KN, Sawyers CL; Clinical Working Group of the Global Alliance for Genomics and Health (GA4GH). All the World’s a Stage: Facilitating Discovery Science and Improved Cancer Care through the Global Alliance for Genomics and Health. Cancer Discov. 2015; 5:1133-6. *Corresponding Author

Dunne PD, McArt DG, Bradley CA, ….. Johnston PG, Lawler M*, Salto-Tellez M, Van Schaeybroeck S. Challenging the cancer molecular stratification dogma: Intratumoral heterogeneity undermines consensus molecular subtypes and potential diagnostic value in CRC. Clin Cancer Res. 2016 22: 4095-104.*Joint Senior Author/ Corresponding Author

Lawler M*,  Le Chevalier T, Banks I, et al. A Bill of Rights for Patients with Cancer in Europe. Lancet Oncol 2014; 15:258-60. *Corresponding Author

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